Leslie Louise Bibb was born in Bismarck, North Dakota, on November 17, 1974, and raised in Nelson County, Virginia. Later she and her mother, along with her three older sisters, moved to Richmond, where Leslie attended an all-girls Catholic high school, St. Gertrude.
After "Popular" ran its course, Bibb segued into a recurring role as an outspoken medical student on the ninth and tenth seasons of "ER" (NBC, 1994-2009). However, her return to series work with "Line of Fire" (ABC, 2003-04), which cast her as a rookie FBI agent, lasted less than a season. She soon joined the cast of the popular "Crossing Jordan" (NBC, 2001-07) as a police detective in the show's final season. Between television assignments, she scored one of her biggest film hits as hapless NASCAR driver Will Ferrell's social-climbing wife in "Talladega Nights: The Ballad of Ricky Bobby" (2006).
In 2012, Bibb returned to television in a role that seemed an updated version of her character from "Popular." On "GCB" (ABC, 2012- ), she played a former high school A-lister-turned-single mom and recovering alcoholic who was forced to move back to her hometown after losing everything due to her embezzler husband. The series received mixed reviews, but the increased profile afforded to Bibb earned her numerous film offers. To her credit, she hewed largely towards comedies, including "Movie 43" (2013), a sketch comedy feature produced by Peter Farrelly and featuring segments directed by Brett Ratner, James Gunn, Bob Oedenkirk and actress Elizabeth Banks. She was also top-billed in the supernatural thriller "7500" (2012) by "Grudge" (2001) director Takashi Shimizu, about an airplane plagued by evil forces.